Description

Nikkomycin S(Z) CAS NO 55727-92-9 is a potent nucleoside-peptide antibiotic belonging to the nikkomycin family, which acts as a competitive inhibitor of chitin synthase. This compound matters for its targeted antifungal activity, offering a specific mode of action against chitin-containing fungi. It is primarily needed by researchers in pharmaceutical development, agricultural science, and biotechnology for antifungal agent discovery, biochemical pathway studies, and as a reference standard.

Application

• Antifungal Research & Development: Serves as a key reference standard and active ingredient in the discovery and evaluation of novel antifungal agents targeting chitin synthesis.
• Biochemical Studies: Used as a specific tool compound to study chitin synthase enzyme kinetics, inhibition mechanisms, and fungal cell wall biosynthesis pathways.
• Agricultural Fungicide Development: Investigated for potential use in developing next-generation, targeted fungicides for crop protection with a specific mode of action.
• Pharmaceutical Intermediates: Acts as a sophisticated building block or precursor in the synthetic chemistry of more complex therapeutic agents.
• Microbiology & Mycology: Employed in laboratory settings to study fungal physiology, susceptibility, and resistance mechanisms against chitin synthase inhibitors.

Basic Information

Product Name	Nikkomycin S(Z)
CAS No.	55727-92-9
Molecular Formula	C20H25N5O10
Molecular Weight	495.44 g/mol
Synonyms	Nikkomycin S(Z); Nikkomycin Sz; Antibiotic S(Z); 6-[(5-Amino-1,5-dideoxy-1-{[(2E,4E)-5-{[(2S,3S,4R,5R)-5-(2,4-Dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-3,4-dihydroxyoxolan-2-yl]methylamino}-1-hydroxypenta-2,4-dien-1-ylidene]amino}-β-L-lyxo-hex-5-ulo-5,2-furanosyl)amino]hexanoic acid; (Z)-Nikkomycin S; Nikkomycin ZS
EINECS	Contact for details

Quality Control

Our Nikkomycin S(Z) is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity research standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.