Description

8-Chloro-1,4-dioxaspiro[4.5]decane is a versatile spirocyclic acetal building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the protected carbonyl group and the chloro substituent serve as orthogonal handles for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of spirocyclic and bridged-ring drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require complex, sterically defined structures.
• Chiral Auxiliary & Ligand Precursor: Serves as a starting material for synthesizing chiral catalysts and ligands used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers with unique thermal and mechanical properties.
• Fragrance & Flavor Chemistry: Employed in the synthesis of musky or woody odorants and complex flavor molecules due to its spirocyclic framework.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, including ring-opening reactions and nucleophilic substitution explorations.

Basic Information

Item	Detail
Product Name	8-Chloro-1,4-dioxaspiro[4.5]decane
CAS No.	55724-03-3
Molecular Formula	C8H13ClO2
Molecular Weight	176.64 g/mol
Synonyms	8-Chloro-1,4-dioxaspiro[4.5]decane; 8-Chlorospiro[1,3-dioxolane-2,1'-cyclohexane]; 1,4-Dioxaspiro[4.5]decane, 8-chloro-; 8-Chloro-1,4-dioxaspiro(4.5)decane; 8-Chloro-1,4-dioxaspiro[4,5]decane; 8-Chloro-1,4-dioxaspiro(4,5)decane; 8-Chloro-1,4-dioxaspiro[4.5]decan; 8-Chloro-1,4-dioxaspiro[4,5]decan
EINECS	Contact for details

Quality Control

Every batch of 8-Chloro-1,4-dioxaspiro[4.5]decane undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by GC or HPLC), identity confirmation (by IR, NMR), and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.