Description

Dolichol Monophosphate Mannose (DPM) is a critical lipid-linked glycosyl donor essential for the biosynthesis of N-linked glycoproteins and GPI anchors in eukaryotic cells. Its primary value lies in enabling fundamental research into protein glycosylation pathways, which are vital for protein folding, stability, and cellular recognition. This high-purity biochemical is indispensable for researchers and manufacturers in pharmaceutical development, biotechnology, and academic biochemistry studying metabolic disorders, congenital diseases of glycosylation (CDGs), and glycoprotein-based therapeutics.

Application

• Biochemical Research: Substrate for studying the enzymatic activity of dolichyl-phosphate mannosyltransferase and other enzymes in the N-glycosylation pathway.
• Drug Discovery & Development: Used in assays to screen for inhibitors of glycosylation enzymes as potential therapeutic targets for cancer, viral infections, and genetic disorders.
• Diagnostics Development: Essential reagent for developing diagnostic tests related to Congenital Disorders of Glycosylation (CDGs).
• Cell Biology Studies: Investigation of protein trafficking, membrane biogenesis, and the role of glycosylation in cell signaling and adhesion.
• Enzyme Characterization: Serves as a standard and substrate for the purification and kinetic analysis of glycosyltransferases.
• Glycoprotein Synthesis: A key intermediate in in vitro systems for synthesizing and studying complex glycoproteins.

Basic Information

Product Name	Dolichol Monophosphate Mannose
CAS No.	55598-56-6
Molecular Formula	C95H153O13P (Typical for Dol-19-P-Man)
Molecular Weight	~1500-1600 g/mol (Dolichol chain length dependent)
Synonyms	Dolichyl phosphate D-mannose; Dolichol-P-mannose; DPM; Dolichyl monophosphomannose; Mannosyldiphosphodolichol; Dolichyl mannosyl phosphate; Dol-P-Man; 2-O-(α-D-Mannopyranosyl)dolichyl monophosphate
EINECS	Contact for details

Quality Control

Our Dolichol Monophosphate Mannose is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, NMR, and mass spectrometry for characterization. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol/water mixtures
Biological Activity	Suitable as substrate for mannosyltransferase assays
Water Content (KF)	< 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.