Description

1-O,3-O,4-o-Tris(Trimethylsilyl)-D-Erythro-2-Pentulose 5-Phosphoric Acid Bis(Trimethylsilyl) Ester is a highly specialized, fully protected derivative of a phosphorylated sugar, designed for advanced synthetic applications where moisture sensitivity is a critical concern. This compound serves as a crucial, air-sensitive building block in the synthesis of complex carbohydrates, nucleotides, and other bioactive molecules, offering precise control over stereochemistry and reactivity. It is primarily utilized by research institutions and pharmaceutical development teams engaged in nucleoside chemistry, glycobiology research, and the development of novel prodrugs or diagnostic agents.

Application

• Advanced Nucleoside & Nucleotide Synthesis: A key protected intermediate for the controlled construction of sugar-phosphate backbones in oligonucleotides and modified nucleosides.
• Glycoconjugate & Carbohydrate Chemistry: Serves as a sophisticated precursor for synthesizing complex oligosaccharides, glycopeptides, and other biologically relevant sugar derivatives.
• Medicinal Chemistry & Prodrug Development: Used in the design and synthesis of phosphate prodrugs to enhance the bioavailability and targeting of therapeutic agents.
• Biochemical Research & Labeling: Employed in the preparation of isotopically labeled (e.g., 13C, 2H) sugar phosphates for metabolic pathway tracing and NMR studies.
• Chemical Biology Tool Development: Acts as a starting material for creating chemical probes to study enzyme mechanisms involving phosphoryl transfer, such as kinases and phosphatases.
• Process Development for API Manufacturing: Used in route scouting and scale-up processes for active pharmaceutical ingredients (APIs) containing phosphorylated sugar motifs.

Basic Information

Product Name	1-O,3-O,4-o-Tris(Trimethylsilyl)-D-Erythro-2-Pentulose 5-Phosphoric Acid Bis(Trimethylsilyl) Ester
CAS No.	55520-87-1
Molecular Formula	C20H51O8PSi5
Molecular Weight	603.06 g/mol
Synonyms	D-Erythro-2-Pentulose, 5-(dihydrogen phosphate), 1,3,4-tris-O-(trimethylsilyl)-, bis(trimethylsilyl) ester; 5-O-Phosphono-D-erythro-2-pentulose 1,3,4-tris(trimethylsilyl) 5-bis(trimethylsilyl) ester; Fully protected D-erythro-2-pentulose-5-phosphate; TMS-protected pentulose phosphate; Phosphorylated pentulose TMS derivative; CAS 55520-87-1
EINECS	Contact for details

Quality Control

Every batch of 1-O,3-O,4-o-Tris(Trimethylsilyl)-D-Erythro-2-Pentulose 5-Phosphoric Acid Bis(Trimethylsilyl) Ester is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency for sensitive research and development applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.