Description

3β-(Trimethylsilyl)Oxy-5α-Cholesta-8,24-Diene is a high-purity, functionalized steroidal intermediate, specifically a trimethylsilyl (TMS) ether derivative of a cholestadiene. This compound is a critical building block in advanced organic synthesis, particularly for the preparation of complex steroid analogs and pharmaceutical active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel steroid-based therapeutics and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial laboratories to study steroid biosynthesis, metabolism, and receptor interactions.
• Fine Chemical Synthesis: Serves as a versatile starting material for the synthesis of complex, high-value steroidal compounds with modified biological activity.
• Reference Standard: Employed as an analytical standard in quality control and method development for steroid analysis using HPLC, GC-MS, or NMR.
• Process Chemistry: Utilized in route scouting and scale-up for the efficient production of steroidal drug candidates.

Basic Information

Product Name	3β-(Trimethylsilyl)Oxy-5α-Cholesta-8,24-Diene
CAS No.	55515-19-0
Molecular Formula	C₃₀H₅₂OSi
Molecular Weight	456.83 g/mol
Synonyms	5α-Cholesta-8,24-dien-3β-ol, trimethylsilyl ether; 3β-Trimethylsilyloxy-5α-cholesta-8,24-diene; (3β)-Cholesta-8,24-dien-3-ol trimethylsilyl ether; 5α-Cholesta-8,24-dien-3β-yl trimethylsilyl ether; TMS ether of 5α-cholesta-8,24-dien-3β-ol; 3β-TMS-5α-cholesta-8,24-diene; Steroid TMS derivative (C29).
EINECS	Contact for details

Quality Control

Our 3β-(Trimethylsilyl)Oxy-5α-Cholesta-8,24-Diene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.