Description

(S)-(+)-2-Isopropyl-2-(4-Methylphenyl)Acetic Acid is a high-purity, single-enantiomer chiral building block essential for asymmetric synthesis. Its defined stereochemistry is critical for producing active pharmaceutical ingredients (APIs) and advanced agrochemicals with high enantiomeric purity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel chiral compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of enantiomerically pure drugs, particularly for anti-inflammatory and central nervous system (CNS) applications.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides where biological activity is enantiomer-dependent.
• Asymmetric Catalysis: Serves as a precursor or ligand in chiral catalyst systems for stereoselective chemical transformations.
• Fine Chemical Production: Employed in the synthesis of complex, high-value specialty chemicals and flavors & fragrances requiring specific chirality.
• Academic & Industrial R&D: A valuable tool for medicinal chemistry research and process development in organic synthesis laboratories.

Basic Information

Product Name	(S)-(+)-2-Isopropyl-2-(4-Methylphenyl)Acetic Acid
CAS No.	55332-35-9
Molecular Formula	C₁₂H₁₆O₂
Molecular Weight	192.26 g/mol
Synonyms	(S)-2-(4-Methylphenyl)-2-isopropylacetic Acid; (S)-(+)-2-(p-Tolyl)-2-isopropylacetic Acid; (S)-2-Isopropyl-2-(p-tolyl)acetic Acid; (S)-α-Isopropyl-4-methylbenzeneacetic Acid; (S)-(+)-Tolylisopropylacetic Acid; (S)-TIPAA; (S)-Methyl IPPA; (S)-Enantiomer of Ibuprofen Precursor
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Isopropyl-2-(4-Methylphenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical and fine chemical applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.