Description

(2R,3R)-3-Amino-2-Hydroxy-3-Phenyl-Propionic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a phenylalanine-like structure with additional stereospecific hydroxyl and amino functionalities. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemical control. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme inhibitors, and other biologically active molecules.
• Peptidomimetics Research: Used to incorporate constrained, non-natural amino acid residues into peptide backbones to enhance stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor for ligands in catalytic asymmetric reactions.
• Bioconjugation & Linker Chemistry: The amino and carboxylic acid groups provide handles for conjugation in antibody-drug conjugate (ADC) linker development.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Agrochemical Synthesis: Intermediate for creating chiral active ingredients with specific stereochemical requirements.

Basic Information

Item	Details
Product Name	(2R,3R)-3-Amino-2-Hydroxy-3-Phenyl-Propionic Acid
CAS No.	55325-50-3
Molecular Formula	C9H11NO3
Molecular Weight	181.19 g/mol
Synonyms	(2R,3R)-3-Amino-2-hydroxy-3-phenylpropanoic acid; (2R,3R)-2-Hydroxy-3-phenyl-β-alanine; (2R,3R)-3-Amino-2-hydroxy-3-phenylpropionic acid; (2R,3R)-3-Phenylisoserine; D-erythro-3-Phenylisoserine; (R,R)-3-Amino-2-hydroxy-3-phenylpropionic acid; (2R,3R)-AHPPA; β-Hydroxy-D-phenylalanine derivative
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-Amino-2-Hydroxy-3-Phenyl-Propionic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.