Description

Phosphoric Acid 3,3-Diethoxy-2-(Trimethylsilyloxy)Propylbis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphate derivative, serving as a key synthetic intermediate and protecting group reagent. This compound is valued for its ability to introduce phosphate functionalities under controlled conditions while offering enhanced stability and solubility in organic media. It is primarily required by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of nucleotides, phospholipids, and other complex bioactive molecules.

Application

• Phosphorylation Reagent: For the controlled introduction of phosphate groups in complex organic synthesis, particularly in nucleotide and oligonucleotide chemistry.
• Phospholipid Synthesis: As a key building block in the preparation of synthetic phospholipids and lipid analogs for drug delivery systems and membrane research.
• Prodrug Development: Utilized in the synthesis of phosphate prodrugs to enhance the bioavailability and targeting of active pharmaceutical ingredients (APIs).
• Polymer Modification: For the functionalization of polymers with phosphate groups to alter surface properties, biocompatibility, or flame retardancy.
• Agrochemical Intermediates: In the synthesis of advanced herbicides, insecticides, and plant growth regulators containing phosphonate or phosphate esters.
• Chemical Biology Probes: As a tool compound for labeling and studying phosphate-mediated biological processes and signaling pathways.
• Catalyst and Ligand Synthesis: For creating novel organophosphorus ligands used in transition metal catalysis and asymmetric synthesis.

Basic Information

Product Name	Phosphoric Acid 3,3-Diethoxy-2-(Trimethylsilyloxy)Propylbis(Trimethylsilyl) Ester
CAS No.	55282-72-9
Molecular Formula	C17H45O7PSi3
Molecular Weight	476.84 g/mol
Synonyms	Bis(trimethylsilyl) (3,3-diethoxy-2-[(trimethylsilyl)oxy]propyl) Phosphate; Phosphoric Acid, (3,3-Diethoxy-2-[(trimethylsilyl)oxy]propyl) Bis(trimethylsilyl) Ester; 2-[(Trimethylsilyl)oxy]-3,3-diethoxypropyl Phosphoric Acid Bis(trimethylsilyl) Ester; TMS-Protected Glycerol Phosphate Derivative; Silyl-Protected Phosphoglycerol Ester
EINECS	Contact for details

Quality Control

Every batch of our Phosphoric Acid 3,3-Diethoxy-2-(Trimethylsilyloxy)Propylbis(Trimethylsilyl) Ester is produced and tested under strict quality management systems. We ensure compliance with relevant industry standards for research and process chemistry. Comprehensive analytical testing, including NMR, HPLC, and GC, is performed to verify identity, purity, and stability. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades can be supplied to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.