Description

[3-(Acetylamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organosilicon-protected phosphonic acid derivative, serving as a crucial synthetic intermediate. This compound is valued for its role in introducing phosphonate functionality under mild conditions, enabling advanced material and pharmaceutical synthesis. It is primarily needed by researchers and manufacturers in the fields of medicinal chemistry, material science, and agrochemical development for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting bone diseases or requiring phosphonate bioisosteres.
• Ligand Synthesis: Precursor for creating sophisticated chelating agents and ligands used in catalysis and metal-organic frameworks (MOFs).
• Surface Modification Agent: Used to functionalize metal oxides and other surfaces to alter wettability, corrosion resistance, or biocompatibility.
• Polymer Additive: Imparts flame retardancy or stabilizes polymers against thermal degradation when incorporated into polymer chains.
• Agrochemical Research: Intermediate in developing new herbicides or plant growth regulators with phosphonate activity.
• Peptide Mimetics: Employed in the design of phosphonopeptide analogs for enzyme inhibition studies.

Basic Information

Product Name	[3-(Acetylamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-89-9
Molecular Formula	C11H28NO4PSi2
Molecular Weight	325.50 g/mol
Synonyms	N-[3-(Bis(trimethylsilyloxy)phosphinyl)propyl]acetamide; (3-Acetamidopropyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[3-(acetylamino)propyl]-, Bis(trimethylsilyl) Ester; Acetamide, N-[3-[bis[(trimethylsilyl)oxy]phosphinyl]propyl]-; 55108-89-9; Silylated (3-Acetamidopropyl)phosphonate; TMS-Protected 3-Acetamidopropylphosphonate
EINECS	Contact for details

Quality Control

Our [3-(Acetylamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.