Description

[1-(Isopropylideneamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester is a specialized organophosphorus compound featuring a silyl-protected phosphonic acid group and an imine functional group. This unique bifunctional structure makes it a valuable advanced synthetic intermediate and ligand precursor in sophisticated chemical synthesis. It is primarily needed by pharmaceutical R&D teams, agrochemical developers, and organometallic chemists for constructing complex molecules and catalysts.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing phosphorus-based bioisosteres.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators where the phosphonate moiety is critical for activity.
• Ligand Synthesis for Catalysis: Serves as a precursor for nitrogen-phosphorus (N,P) bidentate ligands used in transition metal catalysis, such as cross-coupling and hydrogenation reactions.
• Material Science Precursor: Employed in the surface modification of metal oxides and the synthesis of hybrid organic-inorganic materials.
• Peptide Mimetics Research: Utilized in medicinal chemistry to create phosphonate-based analogs of peptides, mimicking phosphate esters in biological systems.
• Flame Retardant Additive Development: Acts as a reactive intermediate in the synthesis of novel, organophosphorus-based flame retardants for polymers.

Basic Information

Product Name	[1-(Isopropylideneamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	55108-65-1
Molecular Formula	C12H30NO3PSi2
Molecular Weight	323.52 g/mol
Synonyms	Bis(trimethylsilyl) [1-(isopropylideneamino)propyl]phosphonate; (1-Isopropylideneaminopropyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-[1-[(1-Methylethylidene)amino]propyl]-, Bis(trimethylsilyl) Ester; N-(1-Diethoxyphosphorylpropylidene)isopropylamine Bis(trimethylsilyl) Ester (related); TMS-Protected Phosphonate Imine
EINECS	Contact for details

Quality Control

Our production of [1-(Isopropylideneamino)Propyl]Phosphonic Acid Bis(Trimethylsilyl) Ester adheres to a strict quality management system. Every batch undergoes comprehensive analytical characterization, including NMR (¹H, ³¹P, ¹³C), HPLC for purity assessment, and GC to monitor residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis of the silyl ester groups. Keep away from strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.