Description

(20β,25R)-3,3-Dimethoxy-5α-Spirostane is a high-purity, synthetic steroidal sapogenin derivative, serving as a critical advanced intermediate in pharmaceutical synthesis. Its precise stereochemistry and functional groups make it an invaluable building block for the development of complex steroid-based active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the production of steroidal drugs and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of steroidal drugs, including corticosteroids, hormones, and other bioactive molecules.
• Research & Development: Used in medicinal chemistry for the discovery and development of new steroid-based therapeutics and for structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex molecular architectures found in natural products and specialty chemicals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	(20β,25R)-3,3-Dimethoxy-5α-Spirostane
CAS No.	55028-82-5
Molecular Formula	C₂₉H₄₈O₅
Molecular Weight	476.70 g/mol
Synonyms	(20β,25R)-3,3-Dimethoxyspirost-5-ene; 3,3-Dimethoxy-5α-spirostan-20β-ol, (25R)-; 5α-Spirostane-3,3-diol, 20β-, 3,3-dimethyl ether, (20β,25R)-; Tigogenin 3,3-dimethyl ether; (25R)-3β,3β-Dimethoxyspirost-5-ene; (20β,25R)-3,3-Dimethoxyspirost-5-ene; 55028-82-5; Tigogenin dimethyl ether
EINECS	Contact for details

Quality Control

Our (20β,25R)-3,3-Dimethoxy-5α-Spirostane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.