Description

α-Cyano-3-Hydroxycinnamic Acid CAS NO 54673-07-3 is a specialized organic acid derivative, widely recognized as a high-performance matrix material for Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry. Its primary value lies in its exceptional ability to facilitate the ionization of peptides, proteins, and other biomolecules, enabling precise and sensitive analytical measurements. This compound is an essential reagent for research and quality control laboratories in the pharmaceutical, proteomics, and life science sectors, where accurate molecular weight determination is critical.

Application

• Primary Matrix for MALDI-MS: The predominant application is as a matrix for the analysis of peptides, proteins, and oligonucleotides in MALDI time-of-flight (TOF) mass spectrometry.
• Proteomics Research: Essential for protein identification, peptide mass fingerprinting, and post-translational modification studies in high-throughput proteomic workflows.
• Pharmaceutical QC & Biomarker Discovery: Used in the quality control of biopharmaceuticals and in clinical research for biomarker detection and validation.
• Polymer Analysis: Employed as a matrix for characterizing synthetic polymers and determining polymer molecular weight distributions.
• Material Science: Investigated for its potential in organic synthesis and as a building block for advanced organic materials.

Basic Information

Product Name	α-Cyano-3-Hydroxycinnamic Acid
CAS No.	54673-07-3
Molecular Formula	C10H7NO3
Molecular Weight	189.17 g/mol
Synonyms	3-Hydroxy-4-cyanocinnamic Acid; 4-Cyano-3-hydroxycinnamic Acid; CHCA; α-Cyano-4-hydroxycinnamic Acid; 2-Propenoic acid, 2-cyano-3-(3-hydroxyphenyl)-, (2E)-; (E)-2-Cyano-3-(3-hydroxyphenyl)acrylic acid; MALDI Matrix CHCA; 3-(3-Hydroxyphenyl)-2-cyanoacrylic acid
EINECS	Contact for details

Quality Control

Our α-Cyano-3-Hydroxycinnamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for identity confirmation, to ensure it meets the high-purity standards required for sensitive analytical applications. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and performance consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	248°C - 252°C
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.