Description

1-(2,2-Difluorocyclopropyl)-3-Nitrobenzene is a specialized fluorinated aromatic intermediate of significant interest in advanced organic synthesis. Its unique structure, featuring a difluorocyclopropyl moiety attached to a nitrobenzene ring, makes it a valuable precursor for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluorocyclopropyl group can impart unique biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced materials with specific optical or electronic properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for cyclopropanation studies, fluorination chemistry, and as a scaffold for library synthesis in medicinal chemistry.
• Ligand and Catalyst Development: The nitro and fluorinated cyclopropyl groups make it a candidate for developing novel chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1-(2,2-Difluorocyclopropyl)-3-Nitrobenzene
CAS No.	54672-46-7
Molecular Formula	C9H7F2NO2
Molecular Weight	199.16 g/mol
Synonyms	3-Nitro-1-(2,2-difluorocyclopropyl)benzene; 1-(2,2-Difluorocyclopropyl)-3-nitrobenzene; Benzene, 1-(2,2-difluorocyclopropyl)-3-nitro-; (2,2-Difluorocyclopropyl)-3-nitrobenzene; m-Nitro-(2,2-difluorocyclopropyl)benzene
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluorocyclopropyl)-3-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.