Description

Z-β-Cyclohexyl-Ala-OH DCHA is a protected amino acid derivative where the amine group is safeguarded by a benzyloxycarbonyl (Z or Cbz) group and the carboxylic acid is complexed with dicyclohexylamine (DCHA). This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced solubility and crystallinity for purification. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key intermediate for the controlled, sequential addition of the β-cyclohexylalanine residue.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptide sequences and cyclic peptides where solution-phase methods are preferred.
• Pharmaceutical Research: A vital precursor in the development of peptide-based drugs, enzyme inhibitors, and receptor agonists/antagonists.
• Bioconjugation: Employed to introduce the hydrophobic β-cyclohexylalanine side chain into proteins or other biomolecules for structure-activity relationship (SAR) studies.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new lead compounds with biological activity.
• Academic Research: A standard reagent in university and institutional labs for studying peptide structure, folding, and function.

Basic Information

Product Name	Z-β-Cyclohexyl-Ala-OH DCHA
CAS No.	54594-40-0
Molecular Formula	C23H36N2O4
Molecular Weight	404.55 g/mol
Synonyms	Nα-Cbz-β-cyclohexyl-L-alanine dicyclohexylamine salt; N-Carbobenzoxy-β-cyclohexyl-L-alanine DCHA salt; Z-β-Cha-OH·DCHA; Cbz-β-cyclohexylalanine dicyclohexylammonium salt; (S)-2-(((Benzyloxy)carbonyl)amino)-3-cyclohexylpropanoic acid compound with dicyclohexylamine (1:1); Nα-Benzyloxycarbonyl-β-cyclohexyl-L-alanine DCHA salt
EINECS	Contact for details

Quality Control

Our Z-β-Cyclohexyl-Ala-OH DCHA is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.