Description

1-tert-Butylazetidin-3-Ol Hydrochloride is a high-purity, protected azetidinol building block essential for advanced organic synthesis. This compound is valued for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the azetidine scaffold can impart unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Custom Synthesis Building Block: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.
• Academic Research: A valuable reagent for methodological development in organic chemistry and heterocyclic compound research at universities and institutes.

Basic Information

Item	Details
Product Name	1-tert-Butylazetidin-3-Ol Hydrochloride
CAS No.	54431-33-3
Molecular Formula	C7H16ClNO
Molecular Weight	165.66 g/mol
Synonyms	3-Hydroxy-1-(tert-butyl)azetidine Hydrochloride; 1-(tert-Butyl)-3-hydroxyazetidine Hydrochloride; 1-tert-Butyl-3-hydroxyazetidine HCl; tert-Butylazetidin-3-ol HCl; Azetidin-3-ol, 1-(1,1-dimethylethyl)-, hydrochloride; 1-Boc-3-hydroxyazetidine Hydrochloride (common precursor name); 3-Azetidinol, 1-(1,1-dimethylethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 1-tert-Butylazetidin-3-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.