Description

Nh-(Peg1-Oh)2 CAS NO 54384-47-3 is a specialized polyethylene glycol (PEG) derivative featuring dual hydroxyl-terminated arms, offering versatile bifunctional reactivity for conjugation and linker chemistry. This compound is valued for its ability to introduce hydrophilicity, improve solubility, and reduce immunogenicity in complex molecular architectures. It is primarily sought by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for applications ranging from drug delivery systems to polymer synthesis.

Application

• Pharmaceutical Intermediates: Serves as a key building block for synthesizing prodrugs, antibody-drug conjugates (ADCs), and PEGylated therapeutics.
• Bioconjugation Linker: Used to covalently attach drugs, proteins, or targeting ligands, leveraging its two hydroxyl groups for sequential or simultaneous coupling reactions.
• Polymer Chemistry: Acts as a hydrophilic initiator or monomer in the synthesis of functionalized polymers, hydrogels, and dendritic structures.
• Surface Modification: Employed to create hydrophilic, protein-resistant coatings on nanoparticles, medical devices, and diagnostic platforms.
• Crosslinking Agent: Utilized in the preparation of crosslinked networks for controlled-release matrices and biocompatible scaffolds.
• Solubility Enhancer: Incorporated into formulations to improve the aqueous solubility and bioavailability of poorly soluble active compounds.

Basic Information

Product Name	Nh-(Peg1-Oh)2 CAS NO 54384-47-3
CAS No.	54384-47-3
Molecular Formula	C6H16N2O4
Molecular Weight	180.20 g/mol
Synonyms	2,2'-(Ethylenedioxy)bis(ethylamine) dihydrochloride; 1,2-Bis(2-aminoethoxy)ethane; PEG-2 Diamine; 2,2'-(Ethane-1,2-diylbis(oxy))di(ethan-1-amine); Ethylene glycol bis(2-aminoethyl) ether; O,O'-Bis(2-aminoethyl)ethylene glycol; 1,11-Diamino-3,6,9-trioxaundecane; Jeffamine EDR-148
EINECS	Contact for details

Quality Control

Our Nh-(Peg1-Oh)2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification, to ensure it meets precise specifications for critical applications. Certificates of Analysis (COA) documenting identity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.