Description

3-Iodo-2-Nitropyridine is a halogenated nitropyridine derivative that serves as a versatile and high-value synthetic building block in advanced organic chemistry. Its molecular structure, featuring both an iodine substituent and a nitro group on the pyridine ring, makes it a critical intermediate for constructing complex molecules through cross-coupling and nucleophilic substitution reactions. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the pyridine core is a common structural motif.
• Material Science: Serves as a building block for creating specialized ligands, organic semiconductors, and photoactive materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form biaryl systems.
• Nucleophilic Aromatic Substitution: The nitro group activates the ring for substitution, allowing for the introduction of amines, alkoxides, and other nucleophiles.
• Chemical Synthesis Reference Standard: Used as a pure standard in analytical laboratories for method development and quality control.

Basic Information

Item	Detail
Product Name	3-Iodo-2-Nitropyridine
CAS No.	54231-34-4
Molecular Formula	C5H3IN2O2
Molecular Weight	249.99 g/mol
Synonyms	2-Nitro-3-iodopyridine; 3-Iodo-2-nitropyridine; 3-Iodo-2-nitro-pyridine; Pyridine, 3-iodo-2-nitro-; 54231-34-4; 3-Jod-2-nitropyridin; 3-iodanyl-2-nitro-pyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-2-Nitropyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity requirements for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be conducted under subdued lighting or in amber glass containers when possible.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.