Description

(R)-But-3-Yn-2-Amine Hydrochloride is a chiral amine hydrochloride salt featuring a terminal alkyne functional group. This compound serves as a versatile and high-value chiral building block in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialized materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Employed in the preparation of chiral ligands, catalysts, and auxiliaries for stereoselective transformations.
• Agrochemical Development: Used in the research and production of chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Click Chemistry: The terminal alkyne moiety allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create diverse molecular architectures.
• Material Science: A building block for advanced polymers and functional materials requiring specific chiral centers.
• Academic & Industrial Research: Serves as a standard or starting material in methodological development and chemical biology studies.

Basic Information

Product Name	(R)-But-3-Yn-2-Amine Hydrochloride
CAS No.	54139-78-5
Molecular Formula	C4H8ClN
Molecular Weight	105.56 g/mol
Synonyms	(R)-3-Butyn-2-amine hydrochloride; (R)-1-Methyl-2-propynylamine hydrochloride; (2R)-But-3-yn-2-amine hydrochloride; (R)-2-Aminobut-3-yne hydrochloride; (R)-But-3-yn-2-aminium chloride; (R)-1-Methylpropargylamine hydrochloride; (R)-3-Butyn-2-aminium chloride
EINECS	Contact for details

Quality Control

Our (R)-But-3-Yn-2-Amine Hydrochloride is manufactured under strict quality control protocols to ensure high chemical and chiral purity, meeting the stringent requirements of research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.