Description

5-Hydroxybenzotriazole is a versatile heterocyclic compound that serves as a critical reagent in modern synthetic chemistry. Its primary value lies in its role as an effective coupling agent and catalyst, significantly improving reaction efficiency and yield in peptide synthesis and other condensation reactions. This high-purity chemical is essential for research and production laboratories in the pharmaceutical, agrochemical, and biotechnology sectors, where precise and reliable chemical intermediates are paramount.

Application

• As a key coupling additive in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) to suppress racemization.
• Used as a catalyst and activator in the synthesis of amides, esters, and other carboxylic acid derivatives.
• Employed in the preparation of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Functions as a corrosion inhibitor in specialized industrial formulations.
• Acts as a stabilizer and intermediate in the production of photographic chemicals and dyes.
• Utilized in biochemical research as a reagent for protein analysis and modification.
• Applied in material science for surface modification and polymer synthesis.

Basic Information

Product Name	5-Hydroxybenzotriazole
CAS No.	54013-40-0
Molecular Formula	C6H5N3O
Molecular Weight	135.12 g/mol
Synonyms	HOBt; 1H-Benzotriazol-5-ol; 5-HOBt; 5-Hydroxy-1H-benzotriazole; Hydroxybenzotriazole; 1,2,3-Benzotriazol-5-ol; 5-Hydroxybenzotriazole monohydrate; NSC 164914
EINECS	258-894-7

Quality Control

Our 5-Hydroxybenzotriazole is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. The product undergoes comprehensive analytical testing, including HPLC for assay and purity determination, to meet the exacting standards required for research and industrial applications. A Certificate of Analysis (COA) detailing all quality parameters is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Melting Point	156°C - 160°C
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.