Description

H-Abu-Otbu Hcl CAS NO 53956-05-1 is a protected amino acid derivative, specifically the hydrochloride salt of H-Abu-Otbu, which serves as a crucial building block in organic synthesis. This compound matters for its role in facilitating the controlled construction of complex peptide chains and other bioactive molecules, enabling precise chemical modifications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and other fine chemicals.

Application

• Peptide Synthesis: As a key intermediate for the controlled introduction of the 2-aminobutyric acid (Abu) residue into peptide sequences during solid-phase or solution-phase synthesis.
• Pharmaceutical Research: Used in the research and development of novel peptide-based drugs, hormone analogs, and enzyme inhibitors.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology: Employed in the synthesis of labeled peptides or probes for studying protein-protein interactions and cellular processes.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Otbu) protecting group allows for selective deprotection under mild acidic conditions, enabling complex multi-step syntheses.
• Fine Chemical Production: Acts as a specialized intermediate in the custom synthesis of complex organic molecules for various industrial applications.

Basic Information

Product Name	H-Abu-Otbu Hcl
CAS No.	53956-05-1
Molecular Formula	C9H19NO3 · HCl
Molecular Weight	225.71 g/mol (Free base: 189.25 g/mol)
Synonyms	H-2-Aminobutyric acid tert-butyl ester hydrochloride; (S)-2-((tert-Butoxycarbonyl)amino)butanoic acid hydrochloride; Boc-Abu-OH · HCl; N-Boc-2-aminobutyric acid hydrochloride; N-(tert-Butoxycarbonyl)-L-2-aminobutyric acid hydrochloride; tert-Butyl (S)-2-aminobutanoate hydrochloride; Boc-L-2-Aminobutyric acid hydrochloride; Abu-Otbu · HCl
EINECS	Contact for details

Quality Control

Our H-Abu-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.