Description

5-(Chlorosulfonyl)-2,4-Difluorobenzoic Acid is a high-purity, multifunctional aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive chlorosulfonyl group and a carboxylic acid moiety on a difluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by R&D and production chemists in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing sulfonamide or benzoic acid derivatives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and sulfonyl chloride groups contribute to biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in the creation of complex ligands for metal catalysis and organocatalysts due to its tunable electronic properties.
• Fluorinated Compound Library: A valuable starting material for generating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Dyestuff and Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments.

Basic Information

Product Name	5-(Chlorosulfonyl)-2,4-Difluorobenzoic Acid
CAS No.	53916-70-4
Molecular Formula	C7H3ClF2O4S
Molecular Weight	256.61 g/mol
Synonyms	2,4-Difluoro-5-(chlorosulfonyl)benzoic Acid; 5-Chlorosulfonyl-2,4-difluorobenzoic Acid; Benzoic acid, 5-(chlorosulfonyl)-2,4-difluoro-; 2,4-Difluorobenzoic-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-(Chlorosulfonyl)-2,4-Difluorobenzoic Acid is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity (by IR and NMR), and impurity profiles. Our quality system is designed to support cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.