Description

n-Nitrosonornicotine is a nitrosamine derivative of nornicotine, a key alkaloid found in tobacco. This compound is of significant interest in analytical and toxicological research due to its role as a tobacco-specific nitrosamine (TSNA). It serves as a critical reference standard and intermediate for researchers and quality control laboratories in the tobacco, pharmaceutical, and chemical safety sectors. Our high-purity grade ensures reliable and reproducible results for your most demanding applications.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of tobacco-specific nitrosamines (TSNAs) in tobacco, smoke, and related products via HPLC, GC-MS, or LC-MS/MS.
• Toxicology and Carcinogenicity Research: Essential biochemical reagent for in vitro and in vivo studies investigating the metabolic pathways, DNA adduct formation, and carcinogenic potential of nitrosamines.
• Pharmaceutical Impurity Profiling: Used in method development and validation to detect and control nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products, ensuring compliance with regulatory guidelines (e.g., FDA, EMA).
• Chemical Synthesis Intermediate: Serves as a specialized building block in organic synthesis for creating novel compounds for research in medicinal chemistry and chemical biology.
• Quality Control & Assurance: Employed by tobacco manufacturers and testing laboratories to monitor and ensure product safety and compliance with industry standards for TSNA levels.
• Environmental and Food Safety Testing: Applied in trace analysis methods to assess nitrosamine contamination in environmental samples, foodstuffs, and agricultural products.

Basic Information

Product Name	n-Nitrosonornicotine
CAS No.	53759-22-1
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	NNN; N-Nitrosonornicotine; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone (Note: This is a common mis-association; NNN is distinct from NNK); N'-Nitrosonornicotine; 1-(3-Pyridyl)-1-butanone, 4-(methylnitrosamino)-; Nornicotine, N-nitroso-; Tobacco-specific nitrosamine NNN
EINECS	Contact for details

Quality Control

Our n-Nitrosonornicotine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results for purity, related substances, and residual solvents. Our quality commitment ensures the material meets the high standards required for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C). Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown solid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Research Grade)
Purity (GC)	≥ 98% (Analytical Standard Grade)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.