Description

(R)-(+)-6-Hydroxy-2,5,7,8-Tetramethylchroman-2-Carboxylic Acid is a high-purity, single-enantiomer compound belonging to the chroman class, serving as a key chiral intermediate and a potent antioxidant. Its value lies in its specific stereochemistry, which is critical for applications in advanced pharmaceutical synthesis and high-performance nutritional research where biological activity is enantiomer-dependent. This product is essential for R&D chemists and manufacturers in the pharmaceutical, nutraceutical, and fine chemical industries seeking a reliable source of this optically active building block.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in cardiovascular and metabolic disease research.
• Antioxidant Research: Used as a reference standard and active ingredient in studies investigating oxidative stress and cellular protection mechanisms.
• Nutraceutical Formulation: Employed in the development of advanced dietary supplements and cosmeceuticals for its potent free radical scavenging properties.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions to produce other enantiomerically pure compounds.
• Biochemical Research: Utilized in enzymatic and receptor-binding assays to study specific biological pathways influenced by tocopherol (Vitamin E) derivatives.
• Material Science: Investigated for incorporation into polymers and coatings to impart antioxidant and stabilizing characteristics.

Basic Information

Product Name	(R)-(+)-6-Hydroxy-2,5,7,8-Tetramethylchroman-2-Carboxylic Acid
CAS No.	53101-49-8
Molecular Formula	C14H18O4
Molecular Weight	250.29 g/mol
Synonyms	(R)-(+)-Trolox; (R)-Trolox; (R)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (R)-(+)-6-Hydroxy-2,5,7,8-tetramethyl-2-carboxy chroman; (R)-Enantiomer of Trolox; (R)-Hydroxy-Trolox; (R)-Vitamin E water-soluble analog; (2R)-6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-(+)-6-Hydroxy-2,5,7,8-Tetramethylchroman-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.