Description

(R)-(Thien-2-Ylcarbonyl)Propionic Acid CAS NO 52780-13-9 is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its enantiomerically pure structure makes it a critical precursor for the development of active pharmaceutical ingredients (APIs) and fine chemicals with specific stereochemical requirements. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture dictates product efficacy.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where the (R)-enantiomer provides specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the manufacture of complex, high-value specialty chemicals and flavors & fragrances.
• Academic and R&D: A valuable reagent for medicinal chemistry research, process chemistry development, and exploring new synthetic methodologies in university and corporate laboratories.

Basic Information

Product Name	(R)-(Thien-2-Ylcarbonyl)Propionic Acid
CAS No.	52780-13-9
Molecular Formula	C8H8O3S
Molecular Weight	184.21 g/mol
Synonyms	(R)-2-(Thiophene-2-carbonyl)propanoic acid; (R)-α-Methyl-2-thiopheneacetic acid; (R)-2-(2-Thienylcarbonyl)propionic Acid; (R)-2-(2-Thienoyl)propionic Acid; (R)-TPA; (R)-Methylthiopheneacetic acid; (R)-2-Thiophen-2-yl-2-methylacetic acid
EINECS	Contact for details

Quality Control

Our (R)-(Thien-2-Ylcarbonyl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.