Description

(3R-Cis)-1-(6-Methoxy-4-Quinolyl)-3-(3-Vinyl-4-Piperidyl)Propan-1-One Monohydrochloride is a high-purity, stereochemically defined chemical intermediate of significant importance in advanced pharmaceutical synthesis. Its precise molecular architecture makes it a critical building block for the development of novel therapeutic agents, particularly in research targeting complex receptor interactions. This compound is primarily required by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers engaged in the production of sophisticated active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of investigational drug candidates, especially those with quinoline and piperidine pharmacophores.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales for new chemical entities (NCEs).
• Reference Standard: Acts as a high-purity analytical standard for method development, quality control, and regulatory submissions for related APIs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of proprietary compounds for clients.

Basic Information

Product Name	(3R-Cis)-1-(6-Methoxy-4-Quinolyl)-3-(3-Vinyl-4-Piperidyl)Propan-1-One Monohydrochloride
CAS No.	52211-63-9
Molecular Formula	C21H26N2O2 • HCl
Molecular Weight	374.91 g/mol (Free base: 338.45 g/mol)
Synonyms	(3R,4R)-1-(6-Methoxyquinolin-4-yl)-3-(3-vinylpiperidin-4-yl)propan-1-one hydrochloride; (3R-Cis)-1-(6-Methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)-1-propanone hydrochloride; 3R-Cis enantiomer of the specified propanone derivative; 4-Quinolinemethanol derivative; A stereoisomer of a quinoline-piperidine ketone.
EINECS	Contact for details

Quality Control

Our (3R-Cis)-1-(6-Methoxy-4-Quinolyl)-3-(3-Vinyl-4-Piperidyl)Propan-1-One Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) starting material applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.