Description

n-Nitroso-n-Propyl-(4-Hydroxybutyl)Amine is a specialized organic compound belonging to the class of nitrosamines. This chemical is significant for its role as a key intermediate and research standard in the study of carcinogenic compounds and metabolic pathways. It is primarily needed by research institutions, analytical laboratories, and pharmaceutical development companies engaged in toxicology studies, method development, and safety testing.

Application

• Research Chemical Standard: Used as a certified reference material (CRM) or analytical standard in gas chromatography (GC) and liquid chromatography (LC) for the quantification and identification of nitrosamine impurities.
• Toxicology and Carcinogenicity Studies: Serves as a model compound in laboratory research to investigate the mechanisms, metabolic activation, and DNA adduct formation of N-nitrosamines.
• Pharmaceutical Impurity Profiling: Critical for developing and validating analytical methods to detect and control potentially genotoxic nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products, ensuring compliance with ICH M7(R1) guidelines.
• Chemical Intermediate: Employed in synthetic organic chemistry for the preparation of more complex molecules in academic and industrial research settings.
• Environmental Analysis: Used in method development for monitoring nitrosamine contaminants in environmental samples, such as water and soil.
• Food Safety Testing: Applied as a standard in assays designed to detect volatile nitrosamines in food products and beverages.

Basic Information

Product Name	n-Nitroso-n-Propyl-(4-Hydroxybutyl)Amine
CAS No.	51938-12-6
Molecular Formula	C7H16N2O2
Molecular Weight	160.22 g/mol
Synonyms	N-Nitroso-N-propyl-4-hydroxybutylamine; N-Nitroso(4-hydroxybutyl)propylamine; N-Nitroso-N-propyl(4-hydroxybutyl)amine; 4-Hydroxybutyl-propyl-nitrosamine; N-Nitroso-N-propyl-4-hydroxybutylamine; N-Propyl-N-(4-hydroxybutyl)nitrosamine; HPBN; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our n-Nitroso-n-Propyl-(4-Hydroxybutyl)Amine is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC, GC). Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the light-sensitive nature of nitrosamines, containers should be amber glass or opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.