Description

Hyaluronic Acid Methyl Ester is a chemically modified derivative of hyaluronic acid, where carboxyl groups are esterified with methanol. This modification significantly enhances its lipophilicity and stability, making it a crucial intermediate for advanced biomaterial synthesis. It is primarily sought after by manufacturers in the pharmaceutical, biomedical, and high-end cosmetic industries for developing controlled-release systems, tissue engineering scaffolds, and long-lasting dermal fillers.

Application

• Biomedical Hydrogels: A key cross-linking agent for creating stable, biocompatible hydrogels used in wound healing and drug delivery matrices.
• Advanced Dermal Fillers: Serves as a modified polymer backbone for next-generation, longer-lasting injectable fillers with improved rheological properties.
• Drug Conjugate & Carrier Systems: Utilized to synthesize prodrugs or polymeric carriers for targeted and sustained release of therapeutic agents.
• Tissue Engineering Scaffolds: Provides a modifiable platform for creating 3D scaffolds that support cell adhesion and proliferation.
• Ophthalmic Formulations: Used in the development of viscoelastic supplements and bioadhesive formulations for ocular drug delivery.
• Cosmetic Actives Carrier: Enhances the skin penetration and stability of encapsulated active ingredients in serums and creams.

Basic Information

Product Name	Hyaluronic Acid Methyl Ester
CAS No.	51434-20-9
Molecular Formula	(C15H23NO11)n
Molecular Weight	Variable (Polymer)
Synonyms	Hyaluronan Methyl Ester; Methyl Hyaluronate; HA-ME; Hyaluronic Acid Methyl Ester Sodium Salt; Methoxy Hyaluronic Acid; Hyaluronic Acid Methylester; Esterified Hyaluronic Acid; Glycosaminoglycan Methyl Ester
EINECS	Contact for details

Quality Control

Our Hyaluronic Acid Methyl Ester is produced under strict quality management systems. Each batch is characterized for critical parameters including degree of esterification, molecular weight distribution, and purity to ensure consistency for sensitive biomedical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or powder
Identification (IR)	Conforms
Degree of Esterification	≥ 85%
Assay (Hyaluronic Acid Basis)	≥ 95%
Molecular Weight (Average)	50 kDa - 500 kDa (Customizable)
pH (1% Solution)	6.0 - 8.0
Loss on Drying	≤ 10.0%
Residue on Ignition	≤ 2.0%
Microbial Limits	Meets USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.