Description

(20S)-6-Methoxy-20-(p-Toluenesulfonoxy-Methyl)-3B,5-Cyclo-5A-Pregnane is a high-purity, advanced steroid intermediate of significant importance in pharmaceutical research and development. Its core value lies in its role as a versatile synthon for the targeted synthesis of complex steroid-based active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and process development scientists working in the pharmaceutical and fine chemical industries, particularly those focused on developing novel therapeutic agents derived from the pregnane skeleton.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of steroidal drugs and novel therapeutic candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a key starting material or intermediate in the scalable manufacturing of complex steroid APIs.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in steroid analysis.
• Biochemical Research: Employed in studies investigating steroid hormone pathways and receptor interactions.

Basic Information

Product Name	(20S)-6-Methoxy-20-(p-Toluenesulfonoxy-Methyl)-3B,5-Cyclo-5A-Pregnane
CAS No.	51231-24-4
Molecular Formula	C30H44O4S
Molecular Weight	500.74 g/mol
Synonyms	6-Methoxy-20-(p-toluenesulfonyloxy)methyl-3β,5-cyclo-5α-pregnane; (20S)-6-Methoxy-20-[(4-methylphenyl)sulfonyloxy]methyl-3β,5-cyclo-5α-pregnane; 3β,5-Cyclo-5α-pregnane-6-methoxy-20-methanol, 20-(p-tolylsulfonate), (20S)-; Pregnane-6-methoxy-20-tosyloxymethyl derivative; Steroid tosylate intermediate
EINECS	Contact for details

Quality Control

Our (20S)-6-Methoxy-20-(p-Toluenesulfonoxy-Methyl)-3B,5-Cyclo-5A-Pregnane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment is to supply material that meets the stringent requirements of pharmaceutical R&D and cGMP starting material guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.