Description

(+)-3-Carboxy-2,2,5,5-Tetramethylpyrrolidinyl-1-Oxy is a stable nitroxide radical compound, widely recognized as a spin label and probe in electron paramagnetic resonance (EPR) spectroscopy. Its value lies in its exceptional stability and the ability to attach to biomolecules via its carboxylic acid group, enabling detailed structural and dynamic studies. This product is essential for researchers and manufacturers in pharmaceutical development, biophysics research, polymer science, and materials characterization who require precise molecular-level insights.

Application

• Spin Labeling in EPR Spectroscopy: Covalently attached to proteins, nucleic acids, and lipids to study conformational changes, dynamics, and distances.
• Biophysical Research: Used as a molecular probe to investigate membrane fluidity, protein folding, and site-directed spin labeling (SDSL) experiments.
• Polymer & Materials Science: Acts as a radical trap or a probe to study polymerization kinetics, polymer chain mobility, and degradation processes.
• Antioxidant & Redox Studies: Serves as a stable radical standard in studies of antioxidant activity and redox reactions.
• MRI Contrast Agent Development: Investigated for use in the design of novel contrast agents due to its paramagnetic properties.
• Structural Biology: Provides long-range distance constraints (up to 80 Å) in conjunction with NMR for integrative structural modeling.

Basic Information

Item	Details
Product Name	(+)-3-Carboxy-2,2,5,5-Tetramethylpyrrolidinyl-1-Oxy
CAS No.	50525-83-2
Molecular Formula	C10H18NO3
Molecular Weight	200.26 g/mol
Synonyms	3-Carboxy-PROXYL; 3-Carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-Carboxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl; 3-CP; Carboxy-PROXYL; (3-Carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyl)oxidanyl; Free Radical PCA
EINECS	Contact for details

Quality Control

Our (+)-3-Carboxy-2,2,5,5-Tetramethylpyrrolidinyl-1-Oxy is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, EPR for radical content verification, and spectroscopic identification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the product should be handled under an inert atmosphere when appropriate to minimize potential oxidation. Keep the container tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
EPR Analysis	Characteristic triplet signal
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.