Description

1-Pyrrolidinyloxy, 3-(Hydroxymethyl)-2,2,5,5-Tetramethyl- is a stable nitroxide radical, specifically a 3-hydroxymethyl-PROXYL derivative, valued for its role as a spin label and spin trap in electron paramagnetic resonance (EPR) spectroscopy. Its primary commercial value lies in enabling the study of molecular dynamics, protein structure, and oxidative stress in complex biological and chemical systems. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise tools for probing free radical processes and molecular interactions.

Application

• Spin Labeling in Biophysics: Covalently attached to biomolecules (proteins, nucleic acids) to study conformation, dynamics, and binding interactions via EPR spectroscopy.
• Spin Trapping Agent: Used to detect, identify, and quantify short-lived free radicals in chemical, biological, and pharmaceutical research.
• Polymer Science & Materials Research: Employed to investigate polymerization kinetics, monitor cross-linking processes, and study the microstructure of polymers and advanced materials.
• Antioxidant & Redox Biology Studies: Serves as a standard or probe in assays measuring oxidative stress, antioxidant activity, and redox signaling pathways.
• MRI Contrast Agent Development: Acts as a building block or precursor for developing novel redox-sensitive contrast agents for magnetic resonance imaging (MRI).
• Catalysis Research: Utilized as a stable radical catalyst or mediator in controlled radical polymerization and other synthetic organic transformations.

Basic Information

Product Name	1-Pyrrolidinyloxy, 3-(Hydroxymethyl)-2,2,5,5-Tetramethyl-
CAS No.	27298-75-5
Molecular Formula	C9H18NO2
Molecular Weight	172.25 g/mol
Synonyms	3-Hydroxymethyl-2,2,5,5-tetramethylpyrrolidin-1-oxyl; 3-Hydroxymethyl-PROXYL; 3-Carbinol-PROXYL; 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidine-1-oxyl; 3-Hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl; 3-HMP; HMPO; 3-Carbinol-2,2,5,5-tetramethylpyrrolidin-1-oxyl
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinyloxy, 3-(Hydroxymethyl)-2,2,5,5-Tetramethyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and EPR for radical content verification, to ensure consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated place. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (EPR)	≥ 97.0% radical content
Melting Point	71 - 75 °C
Solubility	Soluble in water, ethanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.