Description

4-Bromo-2-Trifluoromethylbenzo[H]Quinoline is a high-purity, advanced heterocyclic building block of significant interest in modern synthetic chemistry. Its core value lies in its unique molecular architecture, which combines a bromo-substituted quinoline scaffold with a trifluoromethyl group, enabling precise structural modifications and the introduction of fluorinated motifs. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate for developing novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides, leveraging the biological activity of the quinoline core and the metabolic stability imparted by the trifluoromethyl group.
• Material Science: Serves as a building block for creating organic electronic materials, such as charge-transport layers in OLEDs (Organic Light-Emitting Diodes) and other fluorinated functional polymers.
• Ligand Synthesis: Utilized in organometallic chemistry to create novel nitrogen-containing ligands for catalysis.
• Fluorine Chemistry: An important substrate for further functionalization via cross-coupling reactions, exploiting the reactive bromo substituent for Suzuki, Stille, or Buchwald-Hartwig amination reactions.
• Academic & R&D: A valuable reagent for methodological studies in organic synthesis and for exploring new chemical spaces in high-throughput screening libraries.

Basic Information

Item	Detail
Product Name	4-Bromo-2-Trifluoromethylbenzo[H]Quinoline
CAS No.	50509-76-7
Molecular Formula	C₁₄H₇BrF₃N
Molecular Weight	326.11 g/mol
Synonyms	4-Bromo-2-(trifluoromethyl)benzo[h]quinoline; 2-Trifluoromethyl-4-bromobenzo[h]quinoline; 4-Bromo-2-trifluoromethylbenzo[h]quinoline; Benzo[h]quinoline, 4-bromo-2-(trifluoromethyl)-; 50509-76-7; 4-Bromo-2-trifluoromethyl-benzo[h]quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Trifluoromethylbenzo[H]Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to minimize moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.