Description

2',3'-Isopropylidene-Isocytidine is a key protected nucleoside derivative, specifically an isocytidine analog with an isopropylidene group protecting the 2' and 3' hydroxyls of the ribose sugar. This chemical modification is critical for enabling selective reactions during the synthesis of oligonucleotides and nucleoside-based pharmaceuticals, ensuring high yields and purity in complex synthetic pathways. It is an essential building block for researchers and manufacturers in the fields of antiviral drug development, modified oligonucleotide synthesis, and biochemical research.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel nucleoside analog therapeutics, particularly antiviral and anticancer agents.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and diagnostic applications.
• Biochemical Research: Used in studies investigating nucleic acid chemistry, enzyme mechanisms, and the structure-activity relationships of nucleosides.
• Prodrug Development: The protecting group allows for the creation of prodrug forms of isocytidine, improving stability and bioavailability.
• Labeled Compound Synthesis: Acts as a starting material for introducing isotopic labels (e.g., 13C, 15N) or fluorescent tags into nucleoside structures for tracing studies.

Basic Information

Product Name	2',3'-Isopropylidene-Isocytidine
CAS No.	5975-05-3
Molecular Formula	C12H17N3O5
Molecular Weight	283.28 g/mol
Synonyms	1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-imino-1,2-dihydropyrimidin-2-one; Isocytidine 2',3'-Isopropylidene acetal; 2',3'-O-Isopropylideneisocytidine; 4-Amino-1-((2R,3R,4R,5R)-5-((R)-1,2-Dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one (protected form); NSC 145963; Isocytidine acetonide
EINECS	Contact for details

Quality Control

Every batch of 2',3'-Isopropylidene-Isocytidine is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to ensure it meets the exacting standards required for pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.