Description

4-(2-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolane is a versatile cyclic acetal derivative, also known as a protected form of a diol, valued for its role as a key synthetic intermediate and protecting group in organic synthesis. Its primary commercial value lies in its ability to mask reactive hydroxyl functionalities, enabling complex multi-step reactions in the production of fine chemicals and active pharmaceutical ingredients (APIs). This compound is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking high-purity building blocks for advanced synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial protecting group reagent in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Used as a building block for producing specialty chemicals, fragrances, and flavoring agents where controlled reactivity is required.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialized polyesters and other polymers, influencing material properties.
• Agrochemical Production: Employed as an intermediate in the manufacture of certain pesticides and herbicides.
• Crosslinking Agent: Functions in formulations for coatings, adhesives, and resins that require specific curing properties.
• Laboratory Reagent: Utilized in academic and industrial R&D settings for method development and exploratory organic synthesis.

Basic Information

Product Name	4-(2-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolane
CAS No.	5754-34-7
Molecular Formula	C7H14O3
Molecular Weight	146.18 g/mol
Synonyms	2,2-Dimethyl-4-(2-hydroxyethyl)-1,3-dioxolane; 1,3-Dioxolane, 4-(2-hydroxyethyl)-2,2-dimethyl-; 2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethanol; Glycerol Acetone Ketal; Solketal; (2,2-Dimethyl-1,3-dioxolan-4-yl)methanol (common misnomer); Acetone Glycerin Ketal
EINECS	227-281-0

Quality Control

Our 4-(2-Hydroxyethyl)-2,2-Dimethyl-1,3-Dioxolane is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are available upon request, and we can support compliance needs for cGMP, REACH, and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.430 - 1.435
Density (20°C)	1.060 - 1.080 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.