Description

[S,(+)]-1-o-Phosphono-L-Glycerol is a high-purity, chiral phosphonic acid derivative of glycerol, serving as a critical biochemical building block and enzyme inhibitor. This compound matters for its role as a potent and selective inhibitor of glycerol-3-phosphate dehydrogenase (GPDH), enabling precise metabolic pathway studies. It is essential for researchers and manufacturers in pharmaceutical development, biochemical research, and enzymology, where stereochemical purity and biological activity are paramount.

Application

• Biochemical Research: As a specific inhibitor of sn-glycerol-3-phosphate dehydrogenase (GPDH) in studies of lipid metabolism and the glycerol phosphate shuttle.
• Pharmaceutical Intermediates: Serves as a chiral synthon for the development of novel therapeutic agents targeting metabolic disorders.
• Enzyme Kinetics Studies: Used to investigate enzyme mechanisms and inhibition constants due to its high affinity for the active site of GPDH.
• Diagnostic Reagent Manufacturing: A key component in formulating enzyme assay kits for clinical and research diagnostics.
• Metabolic Pathway Analysis: Employed in cell biology and physiology research to dissect and modulate glycerol and phospholipid biosynthesis pathways.
• Academic & Industrial R&D: A standard reagent for universities and biotech companies exploring energy metabolism and inhibitor design.

Basic Information

Product Name	[S,(+)]-1-o-Phosphono-L-Glycerol
CAS No.	5746-57-6
Molecular Formula	C3H9O6P
Molecular Weight	172.07 g/mol
Synonyms	(S)-(+)-1-o-Phosphonoglycerol; L-α-Glycerophosphonic Acid; (S)-1-(Phosphono)glycerol; (2S)-2,3-Dihydroxypropylphosphonic Acid; sn-Glycerol 1-Phosphonate; Glycerol 1-Phosphonic Acid; L-Glycerol 1-Phosphate Analog; GPDH Inhibitor
EINECS	227-268-6

Quality Control

Every batch of [S,(+)]-1-o-Phosphono-L-Glycerol is produced under strict quality management protocols. We ensure high chemical and chiral purity through advanced analytical techniques. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee reproducibility and reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.