Description

1,3-Dioxolane-4-Methanol is a versatile heterocyclic building block and chiral synthon of significant value in fine chemical synthesis. Its unique structure, featuring both a dioxolane ring and a hydroxymethyl group, makes it a critical intermediate for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop advanced active ingredients and functional materials. Its utility stems from its ability to act as a protected glycol unit or a precursor to more complex ethers and acetals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of antiviral drugs, antibiotics, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where specific stereochemistry is required for efficacy.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with unique solubility or degradation profiles.
• Ligand and Catalyst Preparation: Employed in the development of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Solvent and Reaction Medium: Functions as a polar aprotic solvent for specific organic transformations and electrochemical applications.
• Flavor and Fragrance Industry: Acts as a precursor for synthesizing certain aroma chemicals and flavoring agents.

Basic Information

Product Name	1,3-Dioxolane-4-Methanol
CAS No.	5464-28-8
Molecular Formula	C₄H₈O₄
Molecular Weight	120.10 g/mol
Synonyms	4-(Hydroxymethyl)-1,3-dioxolane; (1,3-Dioxolan-4-yl)methanol; 1,3-Dioxolane-4-methanol; Glyceryl Formal; 4-Hydroxymethyl-1,3-dioxolane; Solketal; Isopropylidene Glycerol; 2,2-Dimethyl-1,3-dioxolane-4-methanol (Note: Some synonyms may refer to related isomers; confirm structure for specific grade).
EINECS	226-763-3

Quality Control

Our 1,3-Dioxolane-4-Methanol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including assay (by GC/HPLC), identification (IR/NMR), and determination of key impurities (water content, residual solvents) to ensure it meets the required specifications for your application. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support compliance requirements for cGMP, ISO, and other relevant regulatory standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.430 - 1.440
Specific Gravity (20°C)	1.180 - 1.220

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.