Description

1-Iodo-2-Nitro-4-Chlorobenzene is a halogenated nitrobenzene derivative of significant importance in advanced organic synthesis. This compound serves as a versatile and high-value building block, particularly valued for its reactivity in cross-coupling reactions and nucleophilic aromatic substitution. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and complex intermediates. Its unique substitution pattern makes it a critical reagent for introducing specific functional groups into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and other crop protection agents.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to form biaryl structures.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and colorants.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating novel chemical entities in academic and industrial labs.

Basic Information

Product Name	1-Iodo-2-Nitro-4-Chlorobenzene
CAS No.	5446-05-9
Molecular Formula	C6H3ClINO2
Molecular Weight	283.45 g/mol
Synonyms	4-Chloro-2-nitro-1-iodobenzene; 2-Nitro-4-chloroiodobenzene; 1-Chloro-4-iodo-3-nitrobenzene; 4-Chloro-2-nitroiodobenzene; 2-Nitro-4-chloro-1-iodobenzene; 3-Nitro-4-chlorophenyl iodide; NSC 403119
EINECS	226-654-8

Quality Control

Our 1-Iodo-2-Nitro-4-Chlorobenzene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	68°C - 72°C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.