Description

1-Bromo-2,3-Dimethoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in providing a reactive bromine substituent adjacent to methoxy groups, enabling precise functionalization for complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for developing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those with substituted benzene cores, such as potential kinase inhibitors or CNS-active compounds.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the bromine atom serves as a handle for further cross-coupling reactions.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where controlled aromatic substitution is critical.
• Chemical Research & Development: A valuable reagent for methodological studies in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution.
• Fine Chemical Production: Used in the multi-step synthesis of dyes, pigments, and other performance chemicals requiring specific bromo-dimethoxy substitution patterns.

Basic Information

Product Name	1-Bromo-2,3-Dimethoxybenzene
CAS No.	5424-43-1
Molecular Formula	C8H9BrO2
Molecular Weight	217.06 g/mol
Synonyms	2,3-Dimethoxybromobenzene; 2-Bromo-1,2-dimethoxybenzene; 3-Bromo-1,2-dimethoxybenzene; 1-Bromo-2,3-dimethoxybenzene; o-Bromoveratrole; Veratrole, 3-bromo-; Bromoveratrole; NSC 404087
EINECS	226-571-4

Quality Control

Our 1-Bromo-2,3-Dimethoxybenzene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.