Description

n-α-Methyl-L-Alanine Hydrochloride is a non-proteinogenic amino acid derivative, specifically the hydrochloride salt of the α-methylated form of L-alanine. This compound is a valuable chiral building block and intermediate in organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications such as peptide mimetics and drug development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptidomimetics Research: Used to create modified peptides with enhanced metabolic stability and bioavailability by incorporating the α-methyl group.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the preparation of enantiomerically pure compounds.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and metal complexation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	n-α-Methyl-L-Alanine Hydrochloride
CAS No.	5325-64-4
Molecular Formula	C4H9NO2 • HCl
Molecular Weight	139.58 g/mol
Synonyms	(S)-2-Aminobutyric Acid Hydrochloride; L-2-Aminobutyric Acid Hydrochloride; (S)-2-Aminobutanoic Acid Hydrochloride; H-α-Me-Ala-OH • HCl; α-Methyl-L-alanine Hydrochloride; L-α-Aminobutyric Acid Hydrochloride; (S)-α-Aminobutyric Acid Hydrochloride; 2-Amino-L-butyric Acid Hydrochloride
EINECS	226-189-3

Quality Control

Our n-α-Methyl-L-Alanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	+14.0° to +16.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.