Description

2-Methylidene-1-Azabicyclo[2.2.2]Octan-3-One is a specialized bicyclic lactam compound featuring a reactive exocyclic methylidene group. This unique molecular architecture makes it a valuable and versatile advanced pharmaceutical intermediate and a key building block in organic synthesis. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel active ingredients and complex molecular structures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug molecules, particularly those with bridged nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its reactive scaffold.
• Fine Chemical Building Block: Employed in custom synthesis and the production of specialty chemicals requiring specific, constrained molecular geometries.
• Academic & Industrial Research: Serves as a key reagent in methodological studies and for constructing novel chemical libraries for screening.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands or organocatalysts due to its nitrogen-containing bicyclic structure.

Basic Information

Product Name	2-Methylidene-1-Azabicyclo[2.2.2]Octan-3-One
CAS No.	5291-26-9
Molecular Formula	C8H11NO
Molecular Weight	137.18 g/mol
Synonyms	2-Methylenequinuclidin-3-one; 3-Quinuclidinone, 2-methylene-; 2-Methylene-3-quinuclidinone; 2-Methylenequinuclidin-3-one; 1-Azabicyclo[2.2.2]octan-3-one, 2-methylene-; Bicyclo[2.2.2]octan-3-one, 2-methylene-1-aza-; 2-Methylene-1-azabicyclo[2.2.2]octan-3-one
EINECS	Contact for details

Quality Control

Every batch of 2-Methylidene-1-Azabicyclo[2.2.2]Octan-3-One is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our quality assurance protocols are designed to meet the stringent requirements of advanced chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.