Description

4-Bromo-1,6-Naphthyridine is a versatile brominated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and material science. This compound is essential for researchers and manufacturers in the agrochemical, pharmaceutical, and specialty chemical industries who require high-purity intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other biologically active nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated naphthyridine scaffold.
• Material Science Research: Serves as a building block for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and other functional organic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Ligand Preparation: Used to synthesize complex chelating ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological systems and enzyme functions.

Basic Information

Item	Details
Product Name	4-Bromo-1,6-Naphthyridine
CAS No.	5268-14-4
Molecular Formula	C8H5BrN2
Molecular Weight	209.04 g/mol
Synonyms	4-Bromo-1,6-naphthyridine; 1,6-Naphthyridine, 4-bromo-; 4-Bromonaphthyridine; 4-Bromo[1,6]naphthyridine; 4-Bromo-1,6-diazanaphthalene
EINECS	Contact for details

Quality Control

Our 4-Bromo-1,6-Naphthyridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.