Description

(+/-)-trans-1,2-Bis-Hydroxymethyl-Cyclobutane CAS NO 5140-07-8 is a versatile chiral building block featuring a rigid cyclobutane core with two hydroxymethyl substituents. This compound is valued for its ability to impart conformational constraint and introduce functional handles in complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for applications in asymmetric synthesis, ligand design, and polymer chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug discovery.
• Asymmetric Catalyst Ligand Precursor: Used to construct chiral phosphines, amines, and other ligands for enantioselective catalysis in fine chemical production.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers with unique thermal and mechanical properties.
• Chemical Biology Probe Development: Utilized to synthesize conformationally restricted analogs of biomolecules for structure-activity relationship (SAR) studies.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and stereochemistry research.

Basic Information

Product Name	(+/-)-trans-1,2-Bis-Hydroxymethyl-Cyclobutane
CAS No.	5140-07-8
Molecular Formula	C6H12O2
Molecular Weight	116.16 g/mol
Synonyms	trans-1,2-Bis(hydroxymethyl)cyclobutane; (±)-trans-1,2-Bis(hydroxymethyl)cyclobutane; 1,2-Cyclobutanedimethanol, trans-; trans-Cyclobutane-1,2-dimethanol; DL-trans-1,2-Bis(hydroxymethyl)cyclobutane; trans-1,2-Di(hydroxymethyl)cyclobutane; Cyclobutane-1,2-dimethanol, trans-; 1,2-Bis(hydroxymethyl)cyclobutane (trans-)
EINECS	225-889-6

Quality Control

Our (+/-)-trans-1,2-Bis-Hydroxymethyl-Cyclobutane is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99:1 trans/cis ratio
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.