Description

4-(Trimethylsilyl)Phenylacetic Acid is a versatile organosilicon building block characterized by its phenylacetic acid core functionalized with a trimethylsilyl group. This compound matters for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure facilitates specific chemical transformations. It is primarily needed by research and development chemists, process engineers, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly for compounds requiring silicon-containing moieties.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trimethylsilyl group can influence bioavailability and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, silicones, and advanced organic-inorganic hybrid materials.
• Liquid Crystal & OLED Materials: Employed in the synthesis of organic semiconductors and liquid crystal compounds for display and lighting technologies.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Protecting Group Strategy: The trimethylsilyl group can serve as a temporary protecting group for aromatic systems in multi-step synthetic pathways.
• Organic Synthesis Research: A valuable reagent for academic and industrial R&D exploring new synthetic methodologies involving silicon chemistry.

Basic Information

Product Name	4-(Trimethylsilyl)Phenylacetic Acid
CAS No.	5112-65-2
Molecular Formula	C11H16O2Si
Molecular Weight	208.33 g/mol
Synonyms	4-(Trimethylsilyl)benzeneacetic Acid; (4-Trimethylsilylphenyl)acetic Acid; α-(4-Trimethylsilylphenyl)acetic Acid; 2-[4-(Trimethylsilyl)phenyl]acetic Acid; p-(Trimethylsilyl)phenylacetic Acid; TMS-Phenylacetic Acid; 5112-65-2; 4-TMS-Phenylacetic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsilyl)Phenylacetic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FT-IR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.