Description

2-Ethynyl-Phenol is a versatile aromatic compound featuring both a phenolic hydroxyl group and a terminal alkyne moiety, making it a valuable bifunctional building block in synthetic organic chemistry. Its unique structure enables it to serve as a key intermediate in the development of complex molecules, particularly through coupling reactions like Sonogashira and click chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for drug discovery, ligand synthesis, and polymer modification.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with acetylene-linked aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that incorporate phenolic and alkyne functionalities.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, resins, and advanced materials with tailored properties.
• Ligand & Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis and organometallic chemistry.
• Click Chemistry Building Block: The terminal alkyne group makes it an ideal substrate for Huisgen cycloaddition (click) reactions to create triazole-linked compounds.
• Research & Development: A crucial reagent in academic and industrial R&D labs for exploring new synthetic pathways and molecular architectures.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex natural products, dyes, and flavor/fragrance compounds.

Basic Information

Product Name	2-Ethynyl-Phenol
CAS No.	5101-44-0
Molecular Formula	C8H6O
Molecular Weight	118.13 g/mol
Synonyms	2-Ethynylphenol; 2-Hydroxyphenylacetylene; o-Ethynylphenol; Phenol, 2-ethynyl-; 1-Hydroxy-2-ethynylbenzene; 2-(Ethynyl)phenol; 2-Ethynyl-1-hydroxybenzene; o-Hydroxyphenylacetylene
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-Phenol is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.