Description

trans-2-(4-Methoxyphenyl)Cyclopropane-1-Carboxylic Acid CAS NO 5087-21-8 is a high-purity, synthetically valuable cyclopropane derivative characterized by its distinct aromatic methoxy substitution. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate in modern organic synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the biological activity of the cyclopropane scaffold.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce stereoselectivity.
• Material Science Research: Investigated as a monomer or building block for advanced polymeric materials with specific optical or mechanical properties.
• Chemical Biology Probes: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, including cyclopropanation and cross-coupling reactions.

Basic Information

Product Name	trans-2-(4-Methoxyphenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	5087-21-8
Molecular Formula	C11H12O3
Molecular Weight	192.21 g/mol
Synonyms	(1R,2S)-rel-2-(4-Methoxyphenyl)cyclopropanecarboxylic Acid; (1R,2S)-2-(4-Methoxyphenyl)cyclopropanecarboxylic Acid; trans-2-(p-Methoxyphenyl)cyclopropanecarboxylic Acid; 2-(4-Methoxyphenyl)cyclopropanecarboxylic Acid; 4-Methoxyphenylcyclopropanecarboxylic Acid; p-Methoxyphenylcyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2-(4-methoxyphenyl)-, trans-
EINECS	Contact for details

Quality Control

Our production of trans-2-(4-Methoxyphenyl)Cyclopropane-1-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure consistency and compliance with customer specifications. Certificates of Analysis (COA) detailing all critical parameters are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (trans-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.