Description

4-Chloro-2,5-Difluoronitrobenzene is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorophenyl or chlorophenyl motifs.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic structure.
• Material Science: Used in the research and production of advanced polymers, liquid crystals, and electronic materials.
• Dye & Pigment Manufacturing: Intermediate for synthesizing complex organic dyes and pigments due to its nitro and halogen functional groups.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it an excellent substrate for displacement reactions with various nucleophiles.

Basic Information

Product Name	4-Chloro-2,5-Difluoronitrobenzene
CAS No.	578-28-9
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	1-Chloro-4,5-difluoro-2-nitrobenzene; 2,5-Difluoro-4-chloronitrobenzene; Benzene, 1-chloro-4,5-difluoro-2-nitro-; 4-Chloro-2,5-difluoro-1-nitrobenzene; NSC 403107; 4-Chloro-2,5-difluoronitrobenzene
EINECS	209-426-2

Quality Control

Our 4-Chloro-2,5-Difluoronitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.