Description

(1S)-3β,4β-Diphenyl-1α,2α-Cyclobutanedicarboxylic Acid CAS NO 528-34-7 is a high-purity, chiral cyclobutane derivative characterized by its unique sterically constrained structure. This compound serves as a critical advanced intermediate and chiral building block for the synthesis of complex, biologically active molecules. It is essential for research and development teams in the pharmaceutical and fine chemical industries who require high-quality, stereochemically defined intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a rigid, stereochemically defined scaffold for constructing complex molecular architectures via catalytic asymmetric reactions.
• Ligand and Catalyst Development: Serves as a core structure for developing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal and mechanical properties due to its rigid, bicyclic core.
• Academic & Industrial R&D: Employed in methodological studies and process development for exploring new synthetic routes to stereochemically complex targets.

Basic Information

Product Name	(1S)-3β,4β-Diphenyl-1α,2α-Cyclobutanedicarboxylic Acid
CAS No.	528-34-7
Molecular Formula	C₁₈H₁₆O₄
Molecular Weight	296.32 g/mol
Synonyms	(1S,2S)-1,2-Diphenylcyclobutane-1,2-dicarboxylic Acid; (1S,2S)-DPCB-Dicarboxylic Acid; (1S,2S)-1,2-Diphenyl-1,2-cyclobutanedicarboxylic Acid; (-)-trans-1,2-Diphenylcyclobutane-1,2-dicarboxylic Acid; (1S,2S)-rel-1,2-Diphenylcyclobutane-1,2-dicarboxylic Acid; (1S,2S)-1,2-Diphenylcyclobutanedicarboxylic Acid; (1S,2S)-DPCB Acid
EINECS	Contact for details

Quality Control

Our (1S)-3β,4β-Diphenyl-1α,2α-Cyclobutanedicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.