Description

Boc-(S)-3-Amino-3-(2,3-Dimethoxy-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a carboxylic acid functional group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular structure and biological activity. It is primarily utilized by pharmaceutical R&D and process chemistry teams for developing novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a constrained, non-proteinogenic amino acid residue with defined stereochemistry.
• Protease Inhibitor Development: Serves as a core structural element in the design of selective inhibitors for various proteases due to its mimetic properties.
• Chemical Biology & Probe Design: Employed in creating labeled probes and activity-based protein profiling (ABPP) reagents to study enzyme function and drug-target interactions.
• Process Chemistry & Scale-up: Provides a reliable, high-quality starting material for optimizing synthetic routes during the transition from laboratory to pilot and commercial-scale manufacturing.

Basic Information

Product Name	Boc-(S)-3-Amino-3-(2,3-Dimethoxy-Phenyl)-Propionic Acid
CAS No.	499995-83-4
Molecular Formula	C₁₆H₂₃NO₆
Molecular Weight	325.36 g/mol
Synonyms	(S)-3-((tert-Butoxycarbonyl)amino)-3-(2,3-dimethoxyphenyl)propanoic acid; Boc-3-Amino-3-(2,3-dimethoxy-phenyl)-propionic acid; (S)-Boc-3-Amino-3-(2,3-dimethoxyphenyl)propanoic Acid; N-Boc-3-Amino-3-(2,3-dimethoxyphenyl)propionic Acid; tert-Butyl (S)-(1-(2,3-dimethoxyphenyl)-3-carboxy-3-oxopropyl)carbamate; Boc-Dmpa-OH; BOC-(S)-3-AMINO-3-(2,3-DIMETHOXY-PHENYL)-PROPIONIC ACID
EINECS	Contact for details

Quality Control

Every batch of Boc-(S)-3-Amino-3-(2,3-Dimethoxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in cGMP environments, and we provide full traceability and documentation support. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.