Description

(R)-3-Amino-3-(4-Bromo-Phenyl)-Propanoic Acid Hydrochloride is a high-purity chiral building block and intermediate of significant value in advanced organic synthesis. Its core value lies in providing a stereochemically defined, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting neurological and psychiatric disorders.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, including γ-aminobutyric acid (GABA) analogs and other neuroactive compounds.
• Asymmetric Synthesis: Serves as a versatile building block for constructing enantiomerically pure molecules via peptide coupling, amidation, and other coupling reactions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new therapeutic agents.
• Process Chemistry Development: Employed in scaling up synthetic routes for APIs, where consistent quality and chiral purity are critical.
• Reference Standard: Utilized as an analytical standard for method development and quality control in pharmaceutical manufacturing.
• Bioconjugation & Probe Development: The amino and carboxylic acid functionalities allow for conjugation to biomolecules or fluorescent tags for biological studies.

Basic Information

Product Name	(R)-3-Amino-3-(4-Bromo-Phenyl)-Propanoic Acid Hydrochloride
CAS No.	499794-78-4
Molecular Formula	C9H11BrClNO2
Molecular Weight	280.55 g/mol
Synonyms	(R)-3-Amino-3-(4-bromophenyl)propanoic acid hydrochloride; (R)-β-Amino-4-bromohydrocinnamic acid hydrochloride; (3R)-3-Amino-3-(4-bromophenyl)propanoic acid hydrochloride; (R)-4-Bromo-β-phenyl-β-alanine hydrochloride; D-3-Amino-3-(4-bromophenyl)propionic acid HCl; (R)-3-(4-Bromophenyl)-3-aminopropanoic acid hydrochloride; (R)-4-Bromophenibut impurity; GABA derivative intermediate
EINECS	Contact for details

Quality Control

Our (R)-3-Amino-3-(4-Bromo-Phenyl)-Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and standard pharmacopeial identification tests. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, purity, and impurity profile to meet the stringent requirements of pharmaceutical R&D and cGMP guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.