Description

1H-Cyclobut[E]Indene-1,2,4-Triol, 2,5,6,7-Tetrahydro-3-Methoxy-, (1R,2S)-Rel- (9Ci) is a complex, stereochemically defined polycyclic compound that serves as a valuable advanced pharmaceutical intermediate and chiral building block in organic synthesis. Its unique fused ring structure and specific stereochemistry make it critical for constructing molecules with precise three-dimensional architectures. This compound is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on developing novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) or anti-inflammatory targets.
• Asymmetric Synthesis: Employed as a sophisticated building block for constructing complex, enantiomerically pure molecules in academic and industrial research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its rigid, polycyclic scaffold.
• Natural Product Analog Synthesis: Serves as a core structure for synthesizing analogs of complex natural products for biological evaluation.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function or biological pathways.
• High-Purity Reference Standard: Supplied as a certified reference material for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	1H-Cyclobut[E]Indene-1,2,4-Triol, 2,5,6,7-Tetrahydro-3-Methoxy-, (1R,2S)-Rel- (9Ci)
CAS No.	499159-79-4
Molecular Formula	C12H14O4
Molecular Weight	222.24 g/mol
Synonyms	rel-(1R,2S)-2,5,6,7-Tetrahydro-3-methoxy-1H-cyclobut[e]indene-1,2,4-triol; (1R,2S)-rel-2,5,6,7-Tetrahydro-3-methoxy-1H-cyclobut[e]indene-1,2,4-triol; 1H-Cyclobut[e]indene-1,2,4-triol, 2,5,6,7-tetrahydro-3-methoxy-, (1R,2S)-rel-; 499159-79-4; Cyclobutindenetriol derivative; Tetrahydro-methoxy-cyclobutindenetriol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our cGMP-compliant mindset ensures traceability and documentation suitable for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.