Description

1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-5-Hydrazinyl- is a high-purity, advanced pharmaceutical intermediate characterized by its hydrazinyl-substituted isoindole-1,3-dione core. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and immunology research. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted protein degraders, such as Proteolysis Targeting Chimeras (PROTACs) and molecular glues.
• Oncology Drug Discovery: Used in research and development of novel anti-cancer agents, leveraging its structural motif for specific protein binding.
• Immunomodulator Synthesis: Serves as a building block for compounds targeting immune pathways and inflammatory diseases.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying protein function and degradation mechanisms in cellular models.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of proprietary drug candidates at various development stages.
• Academic Research: Used in university and institutional labs for fundamental research in medicinal chemistry and drug design.

Basic Information

Product Name	1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-5-Hydrazinyl-
CAS No.	497146-95-9
Molecular Formula	C13H12N4O4
Molecular Weight	288.26 g/mol
Synonyms	5-Hydrazinyl-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-Dioxo-3-piperidinyl)-5-hydrazinyl-1H-isoindole-1,3(2H)-dione; Thalidomide derivative, hydrazinyl-; Lenalidomide/Pomalidomide related intermediate; PROTAC linker precursor; E3 ligase ligand building block; 497146-95-9 (CAS); 5-Hydrazino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
EINECS	Contact for details

Quality Control

Our 1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-5-Hydrazinyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate for prolonged exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.